#Drug-discovery

Showing 51 of 51 repositories tagged #drug-discovery, ranked by stars

K-Dense-AI
K-Dense-AI
scientific-agent-skills

Turn any AI agent into an AI Scientist. The #1 Agent Skills library for science, used by 160,000+ scientists worldwide. 140 ready-to-use skills plus 100+ scientific databases covering biology, chemistry, medicine, and drug discovery. Compatible with Cursor, Claude Code, Codex, Pi, Antigravity, and the open Agent Skills standard.

Score
100
★ 30.4k ⑂ 3.1k +288/day
Python
NVIDIA
NVIDIA
DeepLearningExamples

State-of-the-Art Deep Learning scripts organized by models - easy to train and deploy with reproducible accuracy and performance on enterprise-grade infrastructure.

Score
96
★ 14.8k ⑂ 3.4k +2/day
Jupyter Notebook
deepchem
deepchem
deepchem

Democratizing Deep-Learning for Drug Discovery, Quantum Chemistry, Materials Science and Biology

Score
83
★ 6.8k ⑂ 2.3k +12/day
Python
chemprop
chemprop
chemprop

Message Passing Neural Networks for Molecule Property Prediction

Score
100
★ 2.4k ⑂ 748 +1/day
Python
DeepGraphLearning
DeepGraphLearning
torchdrug

A powerful and flexible machine learning platform for drug discovery

Score
70
★ 1.6k ⑂ 220
Python
mims-harvard
mims-harvard
TDC

Therapeutics Commons (TDC): Multimodal Foundation for Therapeutic Science

Score
65
★ 1.3k ⑂ 219
Jupyter Notebook
a-r-j
a-r-j
graphein

Protein Graph Library

Score
91
★ 1.2k ⑂ 141 +2/day
Jupyter Notebook
molecularsets
molecularsets
moses

Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models

Score
50
★ 979 ⑂ 280
Python
mir-group
mir-group
nequip

NequIP is a code for building E(3)-equivariant interatomic potentials

Score
67
★ 936 ⑂ 209 +3/day
Python
NVIDIA-BioNeMo
NVIDIA-BioNeMo
bionemo-recipes

BioNeMo Recipes: For building and adapting AI models in drug discovery at scale

Score
87
★ 819 ⑂ 170 +4/day
Python
MolecularAI
MolecularAI
REINVENT4

AI molecular design tool for de novo design, scaffold hopping, R-group replacement, linker design and molecule optimization.

Score
100
★ 813 ⑂ 221 +4/day
Python
awslabs
awslabs
dgl-lifesci

Python package for graph neural networks in chemistry and biology

Score
43
★ 807 ⑂ 160
Python
AstraZeneca
AstraZeneca
chemicalx

A PyTorch and TorchDrug based deep learning library for drug pair scoring. (KDD 2022)

Score
35
★ 781 ⑂ 102
Python
Mariewelt
Mariewelt
OpenChem

OpenChem: Deep Learning toolkit for Computational Chemistry and Drug Design Research

Score
39
★ 750 ⑂ 120 +3/day
Python
AgentTeam-TaichuAI
AgentTeam-TaichuAI
ScienceClaw

ScienceClaw is a personal research assistant built with LangChain DeepAgents and AIO Sandbox infrastructure, adopting a completely new architecture beyond OpenClaw. It offers stronger security, better transparency, and a more user-friendly experience.

Score
100
★ 551 ⑂ 62 +4/day
Python
mir-group
mir-group
allegro

Allegro is a code for building highly scalable E(3)-equivariant interatomic potentials

Score
78
★ 490 ⑂ 75
Python
ersilia-os
ersilia-os
ersilia

The Ersilia Model Hub, a repository of AI/ML models for infectious and neglected disease research.

Score
83
★ 301 ⑂ 176 +1/day
Python
Acellera
Acellera
moleculekit

MoleculeKit: Your favorite molecule manipulation kit

Score
74
★ 237 ⑂ 38
Python
pcko1
pcko1
Deep-Drug-Coder

A tensorflow.keras generative neural network for de novo drug design, first-authored in Nature Machine Intelligence while working at AstraZeneca.

Score
48
★ 190 ⑂ 56
Python
hachmannlab
hachmannlab
chemml

ChemML is a machine learning and informatics program suite for the chemical and materials sciences.

Score
67
★ 177 ⑂ 33 +1/day
Python
chao1224
chao1224
ChatDrug

LLM for Drug Editing, ICLR 2024

Score
67
★ 161 ⑂ 10 +1/day
Python
inoue0426
inoue0426
awesome-computational-biology

Awesome list of computational biology.

Score
61
★ 142 ⑂ 13 +2/day
Python
genular
genular
pandora

PANDORA :computer:

Score
0
★ 138 ⑂ 19
Vue
aamini
aamini
chemprop

Fast and scalable uncertainty quantification for neural molecular property prediction, accelerated optimization, and guided virtual screening.

Score
30
★ 135 ⑂ 17
Python
QSong-github
QSong-github
DrugClaw

🦀 Agentic RAG for drug intelligence · 57 skills · 15 task categories · DTI · ADR · DDI · PGx · Repurposing · Powered by LangGraph

Score
93
★ 133 ⑂ 4
Python
THUNLP-MT
THUNLP-MT
dyMEAN

This repo contains the codes for our paper "End-to-End Full-Atom Antibody Design"

Score
60
★ 133 ⑂ 18 +1/day
Python
THUNLP-MT
THUNLP-MT
PepGLAD

Codes for our paper "Full-Atom Peptide Design with Geometric Latent Diffusion" (NeurIPS 2024)

Score
53
★ 127 ⑂ 11 +2/day
Python
jssweller
jssweller
DrugHIVE

DrugHIVE: Structure-based drug design with a deep hierarchical generative model

Score
47
★ 115 ⑂ 16
Python
THUNLP-MT
THUNLP-MT
MEAN

This repo contains the codes for our paper Conditional Antibody Design as 3D Equivariant Graph Translation.

Score
40
★ 109 ⑂ 18
Python
HUBioDataLab
HUBioDataLab
DrugGEN

Official implementation of DrugGEN: Target Specific De Novo Design of Drug Candidate Molecules with Graph Transformer-based Generative Adversarial Networks

Score
33
★ 100 ⑂ 23
Python
rezacsedu
rezacsedu
Drug-Drug-Interaction-Prediction

Drug-Drug Interaction Prediction Based on Knowledge Graph Embeddings and Convolutional-LSTM Network

Score
26
★ 100 ⑂ 30
Jupyter Notebook
SeonghwanSeo
SeonghwanSeo
PharmacoNet

Official Github for "PharmacoNet: deep learning-guided pharmacophore modeling for ultra-large-scale virtual screening" (Chemical Science)

Score
9
★ 98 ⑂ 10
Python
asarigun
asarigun
awesome-denovo-papers

Awesome De novo drugs design papers

Score
13
★ 94 ⑂ 14
coleygroup
coleygroup
shepherd

Training and inference code for ShEPhERD: Diffusing shape, electrostatics, and pharmacophores for bioisosteric drug design [ICLR 2025 oral]

Score
80
★ 93 ⑂ 12
Python
BioTender-max
BioTender-max
awesome-bio-agent-skills

A curated collection of AI agent skills for biomedical research, covering genomics, proteomics, single-cell analysis, clinical AI, and protein design.

Score
87
★ 93 ⑂ 19 +9/day
Python
undeadpixel
undeadpixel
reinvent-randomized

Recurrent Neural Network using randomized SMILES strings to generate molecules

Score
22
★ 93 ⑂ 33
Python
CDDLeiden
CDDLeiden
QSPRpred

A tool for creating Quantitative Structure Property/Activity Relationship (QSPR/QSAR) models.

Score
52
★ 90 ⑂ 21
Jupyter Notebook
nrflynn2
nrflynn2
ml-drug-discovery

The official repository for the book "Machine Learning for Drug Discovery" (Manning Publications)

Score
57
★ 88 ⑂ 30 +1/day
Jupyter Notebook
aksub99
aksub99
MolDQN-pytorch

A PyTorch Implementation of "Optimization of Molecules via Deep Reinforcement Learning".

Score
17
★ 84 ⑂ 27
Python
playmolecule
playmolecule
ligdream

Novel molecules from a reference shape!

Score
17
★ 82 ⑂ 25
Jupyter Notebook
rxdock
rxdock
rxdock

RxDock is a fork of rDock. Note: the latest code is under development. Please do git checkout patched-rdock after clone if you want patched rDock. [IMPORTANT NOTE: pull requests should be posted on GitLab, this is a read-only source code mirror]

Score
0
★ 74 ⑂ 21
C++
zaixizhang
zaixizhang
FLAG

Implementation of ICLR23 paper "Molecule Generation for Target Protein Binding with Structural Motifs"

Score
27
★ 73 ⑂ 9
Python
HongxinXiang
HongxinXiang
awesome-ai-bioinformatics

A curated list of awesome AI and Bioinformatics.

Score
4
★ 56 ⑂ 15 +1/day
JanoschMenke
JanoschMenke
metis

Python-based GUI to collect Feedback of Chemist in Molecules

Score
20
★ 54 ⑂ 13
Python
HzaCode
HzaCode
ChemInformant

⚗️ An all-in-one solution for chemical property retrieval from PubChem.

Score
33
★ 50 ⑂ 4
Python
plainerman
plainerman
DiffDock-Pocket

Implementation of DiffDock-Pocket: Diffusion for Pocket-Level Docking with Side Chain Flexibility

Score
13
★ 39 ⑂ 9
Python
nrohani
nrohani
NDD

Drug-Drug Interaction Predicting by Neural Network Using Integrated Similarity

Score
0
★ 30 ⑂ 17
Python
HySonLab
HySonLab
DrugPipe

DrugPipe: Generative artificial intelligence-assisted virtual screening pipeline for generalizable and efficient drug repurposing

Score
0
★ 20 ⑂ 6 +1/day
Python
Hassantaha999
Hassantaha999
reinvent-UI

An interactive web-based UI app for REINVENT that enables users to generate input files for running REINVENT calculations.

Score
7
★ 20 ⑂ 9
Python
pregHosh
pregHosh
MolCraftDiffusion

A generative AI framework for 3D molecular generation and data-driven molecular design in computational chemistry.

Score
73
★ 16 ⑂ 3
Python
DLS5-Omics
DLS5-Omics
GEMGen

A generative model for phenotypic-based drug discovery

Score
33
★ 11 ⑂ 2
Python
Related Topics
#machine-learning#deep-learning#pytorch#generative-ai#bioinformatics#chemistry#cheminformatics#drug-design#computational-biology#python#materials-science#denovo-design

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