#Bioinformatics

Showing 60 of 218 repositories tagged #bioinformatics, ranked by stars

Developer-Y
Developer-Y
cs-video-courses

List of Computer Science courses with video lectures.

Score
100
โ˜… 82.3k โ‘‚ 11.4k +1/day
K-Dense-AI
K-Dense-AI
scientific-agent-skills

Turn any AI agent into an AI Scientist. The #1 Agent Skills library for science, used by 160,000+ scientists worldwide. 140 ready-to-use skills plus 100+ scientific databases covering biology, chemistry, medicine, and drug discovery. Compatible with Cursor, Claude Code, Codex, Pi, Antigravity, and the open Agent Skills standard.

Score
100
โ˜… 30.4k โ‘‚ 3.1k +288/day
Python
plotly
plotly
dash

Data Apps & Dashboards for Python. No JavaScript Required.

Score
95
โ˜… 24.3k โ‘‚ 2.3k +4/day
Python
biopython
biopython
biopython

Official git repository for Biopython (originally converted from CVS)

Score
90
โ˜… 5.1k โ‘‚ 1.9k +14/day
Python
seandavi
seandavi
awesome-single-cell

Community-curated list of software packages and data resources for single-cell, including RNA-seq, ATAC-seq, etc.

Score
86
โ˜… 3.8k โ‘‚ 1.1k +12/day
google
google
deepvariant

DeepVariant is an analysis pipeline that uses a deep neural network to call genetic variants from next-generation DNA sequencing data.

Score
100
โ˜… 3.7k โ‘‚ 792 +5/day
Python
nextflow-io
nextflow-io
nextflow

A DSL for data-driven computational pipelines

Score
100
โ˜… 3.4k โ‘‚ 788 +4/day
Groovy
scverse
scverse
scanpy

Single-cell analysis in Python. Scales to >100M cells.

Score
100
โ˜… 2.5k โ‘‚ 755 +1/day
Python
shenwei356
shenwei356
seqkit

A cross-platform and ultrafast toolkit for FASTA/Q file manipulation

Score
100
โ˜… 1.6k โ‘‚ 183 +3/day
Go
crazyhottommy
crazyhottommy
getting-started-with-genomics-tools-and-resources

Unix, R and python tools for genomics and data science

Score
78
โ˜… 1.4k โ‘‚ 364 โ€”
Shell
aipoch
aipoch
medical-research-skills

Hundreds of agent skills for medical research, including protocol design, data analysis, evidence insights, and academic writing.

Score
99
โ˜… 1.3k โ‘‚ 87 +64/day
Python
mims-harvard
mims-harvard
TDC

Therapeutics Commons (TDC): Multimodal Foundation for Therapeutic Science

Score
79
โ˜… 1.3k โ‘‚ 219 โ€”
Jupyter Notebook
lightaime
lightaime
deep_gcns_torch

Pytorch Repo for DeepGCNs (ICCV'2019 Oral, TPAMI'2021), DeeperGCN (arXiv'2020) and GNN1000(ICML'2021): https://www.deepgcns.org

Score
76
โ˜… 1.2k โ‘‚ 154 โ€”
Python
a-r-j
a-r-j
graphein

Protein Graph Library

Score
97
โ˜… 1.2k โ‘‚ 141 +2/day
Jupyter Notebook
omicverse
omicverse
omicverse

A python library for multi omics included bulk, single cell and spatial RNA-seq analysis.

Score
76
โ˜… 1.1k โ‘‚ 141 +30/day
Python
moshi4
moshi4
pyCirclize

Circular visualization in Python (Circos Plot, Chord Diagram, Radar Chart)

Score
97
โ˜… 1.1k โ‘‚ 63 +6/day
Python
plotly
plotly
react-plotly.js

A plotly.js React component from Plotly ๐Ÿ“ˆ

Score
0
โ˜… 1.1k โ‘‚ 138 +1/day
JavaScript
broadinstitute
broadinstitute
cromwell

Scientific workflow engine designed for simplicity & scalability. Trivially transition between one off use cases to massive scale production environments

Score
86
โ˜… 1.1k โ‘‚ 382 โ€”
Scala
biotite-dev
biotite-dev
biotite

A comprehensive library for computational molecular biology

Score
67
โ˜… 963 โ‘‚ 138 +3/day
Python
BaranziniLab
BaranziniLab
KG_RAG

Empower Large Language Models (LLM) using Knowledge Graph based Retrieval-Augmented Generation (KG-RAG) for knowledge intensive tasks

Score
55
โ˜… 938 โ‘‚ 112 โ€”
Jupyter Notebook
tanghaibao
tanghaibao
jcvi

Python library to facilitate genome assembly, annotation, and comparative genomics

Score
71
โ˜… 921 โ‘‚ 201 +2/day
Python
COMBINE-lab
COMBINE-lab
salmon

๐ŸŸ ๐Ÿฃ ๐Ÿฑ Highly-accurate & wicked fast transcript-level quantification from RNA-seq reads using selective alignment

Score
100
โ˜… 910 โ‘‚ 186 +5/day
Rust
pysam-developers
pysam-developers
pysam

Pysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.

Score
81
โ˜… 897 โ‘‚ 297 +1/day
Cython
beita6969
beita6969
ScienceClaw

๐Ÿ”ฌ๐Ÿฆž A self-evolving AI research colleague for scientists. 285 skills, zero hallucination, persistent memory.

Score
100
โ˜… 863 โ‘‚ 100 +3/day
TypeScript
awslabs
awslabs
dgl-lifesci

Python package for graph neural networks in chemistry and biology

Score
66
โ˜… 807 โ‘‚ 160 โ€”
Python
dib-lab
dib-lab
khmer

In-memory nucleotide sequence k-mer counting, filtering, graph traversal and more

Score
48
โ˜… 789 โ‘‚ 298 +1/day
Python
deeptools
deeptools
deepTools

Tools to process and analyze deep sequencing data.

Score
62
โ˜… 762 โ‘‚ 222 โ€”
Python
scverse
scverse
anndata

Annotated data.

Score
98
โ˜… 757 โ‘‚ 200 โ€”
Python
scverse
scverse
PyDESeq2

A Python implementation of the DESeq2 pipeline for bulk RNA-seq DEA.

Score
57
โ˜… 757 โ‘‚ 86 +2/day
Python
bebop
bebop
poly

A Go package for engineering organisms.

Score
75
โ˜… 731 โ‘‚ 74 +2/day
Go
pharmai
pharmai
plip

Protein-Ligand Interaction Profiler - Analyze and visualize non-covalent protein-ligand interactions in PDB files according to ๐Ÿ“ Schake, Bolz, et al. (2025), https://doi.org/10.1093/nar/gkaf361

Score
71
โ˜… 702 โ‘‚ 139 +6/day
Python
Edinburgh-Genome-Foundry
Edinburgh-Genome-Foundry
DnaFeaturesViewer

:eye: Python library to plot DNA sequence features (e.g. from Genbank files)

Score
55
โ˜… 693 โ‘‚ 105 +3/day
Python
plotly
plotly
dash-cytoscape

Interactive network visualization in Python and Dash, powered by Cytoscape.js

Score
56
โ˜… 679 โ‘‚ 124 โ€”
Python
cafferychen777
cafferychen777
mLLMCelltype

Cell type annotation for single-cell RNA-seq using multi-LLM consensus

Score
82
โ˜… 649 โ‘‚ 56 +1/day
Python
gamcil
gamcil
clinker

Gene cluster comparison figure generator

Score
81
โ˜… 645 โ‘‚ 79 +1/day
Python
insitro
insitro
redun

Yet another redundant workflow engine

Score
89
โ˜… 594 โ‘‚ 53 +1/day
Python
AgentTeam-TaichuAI
AgentTeam-TaichuAI
ScienceClaw

ScienceClaw is a personal research assistant built with LangChain DeepAgents and AIO Sandbox infrastructure, adopting a completely new architecture beyond OpenClaw. It offers stronger security, better transparency, and a more user-friendly experience.

Score
92
โ˜… 551 โ‘‚ 62 +4/day
Python
sourmash-bio
sourmash-bio
sourmash

Quickly search, compare, and analyze genomic and metagenomic data sets.

Score
92
โ˜… 551 โ‘‚ 93 +3/day
Python
genomoncology
genomoncology
biomcp

BioMCP: Biomedical Model Context Protocol

Score
91
โ˜… 547 โ‘‚ 108 +1/day
Rust
merenlab
merenlab
anvio

An analysis and visualization platform for 'omics data

Score
96
โ˜… 530 โ‘‚ 170 +4/day
Python
openbiox
openbiox
awosome-bioinformatics

A curated list of resources for learning bioinformatics.

Score
94
โ˜… 520 โ‘‚ 125 +4/day
plotly
plotly
Dash.jl

Dash for Julia - A Julia interface to the Dash ecosystem for creating analytic web applications in Julia. No JavaScript required.

Score
90
โ˜… 518 โ‘‚ 45 โ€”
Julia
ablab
ablab
quast

Genome assembly evaluation tool

Score
95
โ˜… 516 โ‘‚ 88 +2/day
AMPL
zeqianli
zeqianli
tgv

Explore genomes in the terminal. Light, blazing fast ๐Ÿš€, vim-motion.

Score
85
โ˜… 480 โ‘‚ 23 +2/day
Rust
aristoteleo
aristoteleo
PantheonOS

A general, evolvable, and distributed agent framework & harness for data science.

Score
93
โ˜… 466 โ‘‚ 64 +9/day
Python
histolab
histolab
histolab

Library for Digital Pathology Image Processing

Score
94
โ˜… 461 โ‘‚ 66 +1/day
Python
scverse
scverse
cellrank

CellRank: dynamics from multi-view single-cell data

Score
91
โ˜… 454 โ‘‚ 56 โ€”
Python
ACEnglish
ACEnglish
truvari

Structural variant toolkit for VCFs

Score
88
โ˜… 418 โ‘‚ 61 โ€”
Python
arvados
arvados
arvados

An open source platform for managing and analyzing biomedical big data

Score
50
โ˜… 418 โ‘‚ 130 โ€”
Go
moshi4
moshi4
pyGenomeViz

A genome visualization python package for comparative genomics

Score
85
โ˜… 412 โ‘‚ 25 โ€”
Python
lightdock
lightdock
lightdock

Protein-protein, protein-peptide and protein-DNA docking framework based on the GSO algorithm

Score
95
โ˜… 402 โ‘‚ 55 +1/day
Python
OmicsML
OmicsML
dance

DANCE: a deep learning library and benchmark platform for single-cell analysis

Score
82
โ˜… 389 โ‘‚ 37 โ€”
Python
DingWB
DingWB
PyComplexHeatmap

PyComplexHeatmap: A Python package to plot complex heatmap (clustermap)

Score
83
โ˜… 389 โ‘‚ 36 +1/day
Python
MLCIL
MLCIL
scikit-fingerprints

Scikit-learn compatible library for molecular fingerprints and chemoinformatics

Score
92
โ˜… 377 โ‘‚ 33 โ€”
Python
immunomind
immunomind
immunarch

๐Ÿงฌ immunarch [R package] โ€“ Multi-Modal Immune Repertoire Analytics for Immunotherapy and Vaccine Design

Score
68
โ˜… 339 โ‘‚ 71 โ€”
R
Marsilea-viz
Marsilea-viz
marsilea

Declarative creation of composable visualization for Python (Complex heatmap, Upset plot, Oncoprint and more~)

Score
80
โ˜… 320 โ‘‚ 14 โ€”
Python
neuhausi
neuhausi
canvasXpress

CanvasXpress: A JavaScript Library for Data Analytics with Full Audit Trail Capabilities.

Score
84
โ˜… 312 โ‘‚ 46 โ€”
R
MariaNattestad
MariaNattestad
Ribbon

A genome browser designed for complex structural variants and long reads.

Score
37
โ˜… 303 โ‘‚ 29 โ€”
JavaScript
wurmlab
wurmlab
sequenceserver

Intuitive graphical web interface for running BLAST bioinformatics tool (i.e. have your own custom NCBI BLAST site!)

Score
86
โ˜… 299 โ‘‚ 121 โ€”
JavaScript
GMOD
GMOD
jbrowse-components

Source code for JBrowse 2, a modern React-based genome browser

Score
87
โ˜… 287 โ‘‚ 86 +1/day
TypeScript
Related Topics
#python#genomics#data-science#visualization#computational-biology#machine-learning#data-visualization#deep-learning#single-cell#docker#llm#drug-discovery

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